As Gabi expressed, Atleti "will play this match with our head, heart and whatever else is necessary to win."
Bragging rights are on the line as Atleti travels south to Madrid community rivals Getafe.
After a crushing 2-1 defeat at Villareal and the last international break of the season, Atletico return to competition this Easter Sunday.
The Europa League remains the best chance for a trophy this season and Atlético travels to Russia in the knockout phase on Thursday.
Lionel Messi hit a 26th-minute free kick and the Barcelona defense held on for a 1-0 win on Saturday. The victory opened up an eight-point gap to Atletico Madrid, all but deciding the title.
Atleti is now just five points back of Barcelona for first. The double game weeks continue as the red and whites must travel to one of the toughest places to play for the biggest match of the season.
The grueling Thursday-Sunday schedule turns the focus right back to La Liga. Atleti return home for a match vs. parent club Athletic Bilbao this weekend.
After a stretch of three games in which Atletico were not themselves, Simeone went back to basics and turned the team around. The question now is if they can sustain this form and outdo Barcelona for the title.
After Barcelona's 1-1 draw at Espanyol, Atletico have a chance to make up ground. However, defeating one of La Liga's most surprising and potent offenses will not be easy.
After a disappointing 1-2 loss to Sevilla at home, Atletico need a win in the Ramón Sánchez Pizjuán.